Post-Doctoral Fellowship: Pharmaceutical Technologies at Council for Scientific and Industrial Research (CSIR)

About The Job

• The CSIR has a vacancy for a Post-Doctoral Fellowship: Pharmaceutical Technologies in the Pharmaceutical Technologies research group within the Chemicals Cluster. The incumbent will focus on flow chemistry process development for active pharmaceutical ingredients (APIs) and related intermediates, including telescoping of process steps to form continuous batch/flow-hybrid process routes and the integration continuous analytical monitoring. He/she will work closely with the research team within the CSIR, and external academic and industry collaborators. This position is based in Pretoria.

Key Responsibilities

• Develop and optimize processes for the preparation of active pharmaceutical ingredients (APIs) and related intermediates using modern manufacturing methods, with a particular focus on flow chemistry;
• Perform translational development, including telescoping of process steps to form continuous batch/flow-hybrid process routes and scaling these processes in a stepwise fashion;
• Implement continuous in-line and/or at-line monitoring of reactor systems;
• Initiate further independent research within the strategic objectives of the Cluster;
• Supervise and/or co-supervise postgraduate students;
• Contribute to the writing of peer reviewed journal publications, of which the successful candidate would be expected to be the lead author for at least one publication per annum.

Qualifications, Skills And Experience

• A Doctoral degree in flow chemistry, synthetic organic chemistry or process chemistry;
• Experience in flow-based process development for small molecule APIs;
• A focus on integration of downstream processing tools within complex multi-step systems would be advantageous;
• Adaptability to change, ability to multi-task and to consistently perform under pressure;
• Good interpersonal skills and the ability to work closely with others in a research group;
• Strong analytical and problem-solving skills; and
• Willing to undertake both local and international training activities.
• All international qualifications require an evaluation report / certificate issued by the South African Qualifications Authority (SAQA).

Closing date: 06 February 2023